肝外胆管癌组织中Bcl-2的表达及意义

Expression of Bel-2 in Extrahepatic Biliary Carcinoma

目的 了解抗凋亡基因Bcl-2在肝外胆管癌和良性胆管疾病组织中的表达及其与胆管癌分化程度的关系.方法 利用免疫组织化学方法检测了46 例肝外胆管癌,10例胆总智囊肿,5例慢性胆管炎胆管壁组织Bcl-2蛋白的表达.结果胆管癌Bcl-2蛋白表达阳性率为(43.3%).其中高分化腺癌Bcl-2蛋白阳性率为(64.3%).中分化腺癌Bcl-2蛋白阳性率为(42,8%),低分化腺癌BCl-2蛋白阳性率为(18.1%).10例胆总管囊肿及5例慢性胆管炎的胆管壁组织均无表达.结论1 Bcl-2蛋白在胆管癌与良性胆管疾病中表达有显著差异,它的过度表达与肝外胆管癌的发生有关.2 胆管癌分化程度越高,其Bcl-2表达越高,而分化程度越低,其Bcl-2表达越低.提示Bcl-2蛋白在肝外胆管癌表达与细胞分化程度有关.

Objective In order to study the expression of Bcl-2 in extrahepatic biliary carcinomas and benign diseases of bile ducts. Methods Bcl-2 expression was studied immunohistochemically in 46 cases of biliary carcinomas, 10 cases of biliary cysts and 5 cases of chronic biliary inflammation. Results The positive rate of Bcl-2 in biliary carcionomas is 43.3%. The one in well differentiated carcinomas is 64.3%, in moderate differentiated ones is 42.8% and in poor differentiated ones is 18.1%. No Bcl-2 expression was found in benign bile buct diseases. Conlusion 1 Over expression of Bcl-2 was observed in biliary carcinomas. 2 Bcl-2 expression in biliary carcinomas is correlated with their differentiation.