前列腺素E_1治疗老年糖尿病肾病的临床观察

Clinical effect of prostaglandin E_1 in the diabetic nephropathy in elderly patients

目的 探讨前列腺素E1治疗老年糖尿病肾病 (DN)的临床应用价值。方法 72例老年DN患者分为对照组 35例 ,治疗组 37例 ,两组的基础治疗相同 ,治疗组给以PGE1(凯时 ) 10 μg加于生理盐水 2 5 0ml中静滴 ,每天 1次 ,共两周。观察分析两组治疗前后 2 4小时尿微量白蛋白 (UAE)及血液流变指标。结果 对照组治疗前后UAE及各血液流变指标均无明显改变 (P >0 0 5 )。治疗组治疗后UAE显著下降 (P <0 0 1) ,全血黏度、血浆黏度、纤维蛋白原、红细胞聚集指数均低于治疗前 ,而红细胞变形指数则高于治疗前 (均为P <0 0 5或 0 0 1)。两组均未发现肝、肾功能、血液及神经系统损害 ,静脉滴注过程亦未见不良反应。两组治疗前后各指标差值比较有明显改变 (均为P <0 0 5或 0 0 1)。结论 PGE1(凯时 )治疗老年DN疗效明显 ,不良反应少 ,使用安全。

Objective To explore the effect of prostaglandin E 1 (Kaishi) in the diabetic nephropathy in elderly patients.Methods 72 patients with diabetic nephropathy in elderly were divided into the control group (35 cases) and the therapy group (37 cases) which were treated with prostaglandin E 1 .All patient were treated conventionally for diabetic and hypertension . Microalbuminuria(UAE) and curative indices were examined before and after treatment.Results UAE and curative indices between before and after treatment of the control group were not significantly different (P>0.05) . After treatment in the therapy group compared with before , UAE,total blood viscosity,plasma viscosity,fibrinogen,erythrocyte agglutinative index were significantly lower (P<0.01～0.05); erythrocyte distortion index was significantly raised (P<0.05). Compared with the control group , which differetial of each index between before and after treatment had significant difference(P<0.01～0.05).Conclusion Prostaglandin E 1 (Kaishi ) is an effective and safe drug in treatment of the diabetic nephropathy in elderly patients.