潜伏梅毒患者脑脊液梅毒抗体检测的临床意义

Clinical significance of cerebrospinal fluid Treponemal Antibody tests in patients with latent syphilis

目的 检测潜伏梅毒患者脑脊液中的梅毒抗体 ,探讨脑脊液检测对无症状神经梅毒诊断的临床意义。方法 对6 0例潜伏梅毒患者进行脑脊液常规及VDRL、FTA -Abs、TPHA和IgM检测。 结果 常规检测 6 3.3%蛋白升高 ,30 %葡萄糖升高 ;2 9例患者脑脊液梅毒抗体检测阳性 ,其中VDRL、FTA -Abs、IgM和TPHA阳性者分别为 2、6、7、14例 ,4种方法检出率有显著性差异 (P <0 .0 5 )。结论 脑脊液梅毒抗体检测有助于潜伏梅毒患者中无症状神经梅毒的诊断 ,对潜伏梅毒患者的治疗有重要意义。

Objective To measure the Treponemal hronic Diseases Antibody in CSF of latent syphilitic patients,and investigate it's clinical significance to the diagnosis of asymptomatic neurosyphilis.Methods Routine test and Treponemal antibodies tests(RPR、VDRL、FTA-Abs、TPHA and TP-IgM) were measured in cerebrospinal fluid of 60 latent syphilitic patients.Results 63.3% had elevated protein concentration and 30% had elevated glucose concentration in CSF. Treponemal antibodies tests: 29(48.33%) had Treponemal antibodies in CSF: 2(3.33%)VDRL, 6(10%)FTA-Abs、7(11.67%)TP-IgM and 14(23.33%)TPHA were positive; there were significantly differences among these four methods measured in CSF.Conclusion CSF Treponemal antibodies tests are helpful in diagnosing asymptomatic neurosyphilis of latent syphilitic patients, and these are significant to the treatment of latent syphilitic patients.