苦参素对慢性肝炎TNF-α、IL-6的影响

The Effect of Kurorinone on the Serum Level of TNF-α and IL-6 in patients with Chronic Hepatitis B

目的 探讨苦参素对慢性肝炎TNF -α、IL -6的影响。方法 87例CHB ,随机分为A、B两组。A组采用苦参素治疗 ;B组甘利欣治疗 ,疗程 3个月。观察肝脏组织及血清中肝功、肿瘤坏死因子 (TNF -α)、IL -6的变化。结果 苦参素可明显改善肝细胞损伤 ,显著降低血清中TNF -α、IL -6的水平 ,与对照组对比差异有显著性 (P <0 0 5 )。结论 苦参素的保肝作用 ,可能与抑制TNF -α、IL -6等介质释放有关。

Objective To explore the effects of kurorinone on the serum level of TNF-α and IL-6 in the patients with chronic hepatitis B (CHB). Methods 87 patients with CHB were randomly divided into groups A and B. Patients in group A (n=45) and group B (n=42) received kurorinone and diammonium glycyrrhizin treatment, respectively, for 3 months. The liver histopathological changes were observed, and liver function and the serum level of TNF-α and IL-6 in the patients with CHB were detected after treatment. Results Compared with group B, liver injury and liver function of the patients in group A were obviously ameliorated, and the serum level of TNF-α and IL-6 significantly decreased (P<0.05). Conclusion These results indicated that kurorinone has protective effect on hepatic necrosis, which may be related to the inhibition of TNF-α and IL-6 release.