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三叶因子1在胃癌及癌前病变胃黏膜中的表达改变 被引量：1

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摘要 目的:测定三叶因子1在正常、胃癌、不典型增生及肠化胃黏膜中的表达情况,探讨TFF1在胃癌的发生、发展中的作用及意义. 方法:应用免疫组化方法测定各种条件下胃黏膜中TFF1的表达情况,通过图像分析软件分析其阳性信号平均光密度值了解其表达情况. 结果:胃腺癌患者癌旁组织表达(0.51±0.07)明显高于正常胃黏膜(0.44±0.06,P<0.001),而腺癌组织的表达强度则与癌组织的分化程度呈正比,分化程度愈低,表达愈弱,低分化腺癌无阳性表达,中、高分化腺癌表达(0.41±0.07) 略低于正常黏膜(P>0.05);不典型增生胃黏膜TFF1表达(0.57±0.03)明显高于正常胃黏膜(P<0.001);肠化胃黏膜无TFF1阳性表达,但肠上皮化生周围的胃黏膜TFF1表达(0.45±0.07)与正常胃黏膜相比无统计学差异(P>0.05). 结论:TFF1在癌旁组织及不典型增生胃黏膜中表达增强提示其可能与肿瘤抑制及分化机制有关,而在癌组织中表达减弱,且分化程度越低表达越弱可能与癌组织腺体及细胞破坏、TFF1的分泌减少有关.
作者 任建林 罗金燕 卢雅丕 陈建民 王琳
机构地区 西安交通大学第二医院消化内科 厦门大学医学院第一临床学院
出处 《世界华人消化杂志》 CAS 2004年第9期2188-2190,共3页 World Chinese Journal of Digestology
关键词 表达 胃黏膜 正常 胃癌 不典型增生 三叶因子 分化程度 情况 高分 结论
分类号 R735.2 [医药卫生—肿瘤] R573 [医药卫生—消化系统]
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参考文献16

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共引文献17

同被引文献42

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世界华人消化杂志
2004年 第9期

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