土茯苓二氢黄酮醇类成分研究

Studies on dihydroflavonol glycosides from rhizome of Smilax glabra

目的 :研究土茯苓的化学成分。方法 :用硅胶、大孔树脂、ODS柱色谱及HPLC方法进行分离纯化 ,根据理化性质和光谱数据进行结构鉴定。结果 :分离鉴定了 5个二氢黄酮醇苷类化合物 ,分别为落新妇苷 (1) ,新落新妇苷 (2 ) ,异落新妇苷 (3) ,新异落新妇苷 (4 ) ,(2R ,3R) 花旗松素 3′ O β D 吡喃葡萄糖苷 (5 )。 结论 :化合物 2 ,4 。

Objective: To investigate the chemical con st ituents from the rhizomes of Smilax glabra. Method: Th e compounds were isolated by column chromatography with silica gel, Diaion HP-2 0 and ODS as packing materials, and HPLC. Their structures were determined on th e basis of their spectral evidence. Result: 5 dihydro-fla vonol glycosides were identified as: astilbin (1), neoastilbin (2), isoastilbin (3), neoisoastilbin (4), (2R, 3R)-taxifolin-3′-O-β-D-pyr anglucoside (5). Conclusion: Compounds 2, 4, 5 were isolat ed from this plant for the first time.[