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维生素D受体基因多态性对慢性肾功能不全患者骨密度和甲状旁腺功能的影响 被引量：2

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摘要 维生素D受体基因(VDR)位于人类第12号染色体上,该基因全长约4605个碱基对,基因转录产物为VDR蛋白.活性维生素D3与靶器官上的VDR结合后,在转录水平改变靶器官上特定蛋白质表达水平,产生不同的生物效应,可影响骨密度(BMD)及血液中甲状旁腺激素含量.我们观察了VDR基因多态性对慢性肾功能不全患者BMD和甲状腺功能的影响,现报告如下.
作者 张建伟 傅淑霞 程刚
机构地区 河北医科大学第二医院 济宁医学院附属医院
出处 《山东医药》 CAS 北大核心 2004年第29期15-17,共3页 Shandong Medical Journal
关键词 骨密度 患者 慢性肾功能不全 维生素D受体基因多态性 甲状旁腺功能 BMD 靶器官 转录水平 碱基对 生物效应
分类号 R681 [医药卫生—骨科学] R692.5 [医药卫生—泌尿科学]
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参考文献6

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同被引文献26

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二级引证文献9

山东医药
2004年 第29期

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