小儿肺炎病原学检测分析

Study on pathogen result of children pneumonia

目的 了解小儿肺炎感染病原学情况。方法 用免疫荧光法(IFA)检测113例小儿肺炎患儿血清中的副流感病毒Ⅰ(PIV Ⅰ)、副流感病毒Ⅱ(PIVⅡ)、副流感病毒Ⅲ(PIVⅢ)、呼吸道合胞病毒(RSV)、柯萨奇B1病毒(CB1V)、嗜血流感杆菌(HI)、肺炎支原体(MP)和肺炎克雷伯杆菌(KP)8种病原体的特异性IgM抗体。结果 113例肺炎病例血清特异性IgM阳性76例,阳性率67.3％,其中RSV 45例,阳性率39.8%,CB1V 32例,阳性率28.3％,PIVⅡ28例,阳性率24.8％,PIVⅢ26例,阳性率23.0％,HI9例,阳性率8.0％,MP4例,阳性率3.5%,KP 2例,阳性率1.8％,PIV Ⅰ 0例。单纯病毒病原感染61例,感染率54.0％,两种及两种以上病原体混合感染41例,占36.3%。结论 病毒仍是小儿肺炎的主要致病病原,其中以RSV阳性率最高,CBV逐渐成为小儿肺炎的主要致病病毒之一。

Objective To comprehend the pathogens of children pneumonia. Methods Eight kinds of special IgM antibodies against parainfluenza viruses Ⅰ ,Ⅱ ,Ⅲ( PIV Ⅰ , PIV Ⅱ , PIV Ⅲ) , respiratory syncytial ( RSV) , coxsackievirus(CB1 Ⅴ ), hemophilus influenzae (HI), mycoplasma pneumonia (MP) and klebsiellae pneumonia (KB) in 113 cases of children pneumonia patient's blood serum were inspected by 1FA. Results There were 76 positive results of special IgM antibody in blood serum among 113 cases. ( at a ratio of 67. 3% ) . It composed 45 positive cases of RSV (39.8% ), 32 CB1V (28.3%) , 28 PIV Ⅱ(24.8% ) , 26 PIV Ⅲ(23.0%), 9 HI(8.0% ) , 4 MP (3.5% ) , 2 KP(1. 8% ) and 0 PIV Ⅰ (0% ). There were 61 cases of single virus infections, at a ratio of 54.0% whilst 41 cases were infected by two or more pathogens with a ratio of 36. 3% . Conclusion children pneumonia is caused mainly by viruses, specially RSV which occupied the highest positive percentage. Meanwhile CBV gradually became one of the main causing pathogens for children pneumonia.