摘要
目的 :研制布洛芬口服混悬液 ,并建立质量控制方法。方法 :用HPLC法检测其含量及有关物质 ,并进行方法验证。结果 :布洛芬在 35～ 6 5 μg·ml-1范围内线性关系良好。回归方程为Y =4 8.2× 10 4X +14 .9× 10 4,R2 =0 .9995。结论 :本制剂质量稳定 ,含量测定方法准确简便 ,有关物质的控制可靠。
Objective: Develop the formula and quality control method of ibuprofen suspension and test the stability. Method: Prepare ibuprofen oral suspension, assay and test related oral substances with HPLC and validate. Result: This preparation is stable, it is credible to assay and control related substances with HPLC. Conclusion: The formula and HPLC method are feasible.
出处
《中国药师》
CAS
2004年第11期867-869,共3页
China Pharmacist
关键词
布洛芬口服混悬液
处方工艺
质量控制
Ibuprofen
Oral suspension
Formula and process
Quality control
