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癫痫耐药的分子机制 被引量：1

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摘要 约1/3的癫痫患者对抗癫痫药物(AEDs)耐药。癫痫耐药是一个复杂的过程,可能涉及多药转运体P-糖蛋白(Pgp)和多药耐药相关蛋白(MRP),这些蛋白质及其mRNA在脑内皮的表达增加,主动从中枢神经系统清除AEDs,降低AEDs在致痫组织的有效浓度;此外,某些药物作用的分子靶点(如电压依赖性Na^+通道)也可能发生改变。
作者 王宇卉 邵福源
机构地区 解放军第 第二军医大学长征医院神经科
出处 《国外医学（神经病学．神经外科学分册）》 2004年第5期488-491,共4页 Foreign Medical Sciences（Section On Neurology & Neurosurgery）
关键词 多药耐药相关蛋白 癫痫 分子机制 脑内 分子靶点 药物作用 内皮 Na^+通道 转运体 RNA
分类号 R742.1 [医药卫生—神经病学与精神病学] R735 [医药卫生—肿瘤]
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参考文献20

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同被引文献12

  • 1Noebels J L,Avoli M,Rogawski M,et al.'Jasper's Basic Mechanisms of the Epilepsies' Workshop.Epilepsia,2010,5 l(Suppl 5):1-5.
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  • 4刘金民,郑香春,江涛.中药柴贝止痫汤对难治性癫痫大鼠发作情况及多药耐药基因表达的研究.广州:中华中医药学会脑病分会成立大会暨2008年全国中医脑病学术研讨会,2008.
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国外医学（神经病学．神经外科学分册）
2004年 第5期

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