对烷基苯甲醛的合成

Synthesis of 4-Alkylbenzaldehyde

以甲苯、乙苯、异丙苯、叔丁基苯为基本原料,分别经Blanc氯甲基化、乌洛托品氧化(Sommelet)两步反应,合成了4种对烷基苯甲醛--对甲基苯甲醛、对乙基苯甲醛、对异丙基苯甲醛、对叔丁基苯甲醛。探讨了各步反应机理及原料配比、反应温度、催化剂等因素对反应的影响,确定了合成4种对烷基苯甲醛的最佳反应条件。在选择的实验条件下,总收率都在75％以上。产物结构经元素分析、IR和1H NMR确证,用液相色谱进行定量分析。

Four kinds of 4 - alkylbenzaldehyde-4 - methyl - benzaldehyde, 4 - ethyl - benzaldehyde, 4 - (1 -methylethyl)-benzaldehyde, 4 - ( 1, 1 - dimethylethyl)-benzaldehyde were synthesized seperately from four relevant alkylbenezenes-4 - methyl benzene, 4 - ethyl benzene, 4 - ( 1 - methylethyl) benzene, 4 - ( 1, 1 -dimethylethyl) benzene, taken as raw materials and processed by two step reaction,Blanc chloromethylation and Sommelet oxidation. Reaction mechanism, and effects of different feed ratio, reaction temperature, catalysts of Blanc chloromethylation and Sommelet oxidation were studied. Optimum reaction conditions were obtained. The product yields were all above 75% .The products were characterized by mean of HPLC,IR and :H NMR.