大豆膳食对去卵巢大鼠血脂的影响

The effects of soybean diet on lipoiod metabolism in ovariectomized rats

目的 研究大豆膳食对去卵巢大鼠血脂的影响。方法 180 g左右SD雌性后大鼠手术切除双侧卵巢后 ,随机分成手术对照组、注射雌激素组、高剂量大豆膳食组、中剂量大豆膳食组、低剂量大豆膳食组 ,每组 8只 ,另设未手术对照组 ( 8只 )。分组后喂养指定饲料。试验 10wk后处死动物 ,测定血清总胆固醇 (TC)、血清甘油三酯(TG)、低密度脂蛋白 (LDL)、高密度脂蛋白 (HDL)、子宫和腹腔脂肪重。结果 手术对照组TC ,LDL明显高于未手术组和高剂量大豆膳食组 ;与未手术组、雌激素组和高剂量大豆膳食组比较 ,手术对照组TG明显降低。不同剂量大豆膳食组子宫系数明显高于手术对照组 ,但低于未手术对照组 ;雌激素组各指标与未手术组无明显差异。结论 大豆膳食可使去卵巢大鼠TC ,LDL降低 。

Objective To study the influence of soybean diet on the serum lipoiod metabolism in ovariectomized rats. Methods SD ovariectomized rats, weight 180g±, were randomly divided into five groups: control group ovariectomized,(no estrogen injection and no soybean diet), estrogen injection group, three soybean diet groups (low dose of soybean diet , middle dose of soybean diet and high dose of soybean diet , there are 8 rats in each group. Another 8 non-operation rats work as the positive control group. After ten weeks′ test, the rats were sacrificed, and uterus and adipose of abdomen were weighted. Totalcholesterol(TC), Triglycerides (TG), LDL, and HDL in the serum were measured. Results The level of TC and LDL in the serum of ovariectomized rats increased significantly, compared with that in control group and high dose of soybean diet group. The level of TG in the serum of control group ovariectomized rats decrease significantly, compared with that in non-operation group,high dose of soybean diet group and estrogen injection group. Although relative uterus weights in L- M- and h- dose of soybean diet groups were all higher than that in operation group, they were lower than that in the non-operation control group.Those norm in estrogen injection group were not different, compared with that in non-operation control group. Conclusions soybean diet could decrease the TC and LDL of serum in ovariectomized rats and had significantly improve on lipoprotein metabolism.