炎症在冠状动脉疾病中的作用

THE ACTION OF INFLAMMATION IN CORONARY HEART DISEASE

目的 :研究炎症反应与冠状动脉疾病的相关性。方法 :将急性心肌梗死 ( AMI) 1 1 4例 ,不稳定型心绞痛 ( UAP) 3 9例 ,原发性高血压 ( EH) 2 8例 ,分别测定血清中 Ig A、Ig G、CRP、IL-6、TNF-α的水平进行对比研究。结果 :a.Ig A、Ig G,在 AMI、UAP、EH三组的数值均在正常范围之内 ,但是三组相比 ,其中 Ig G数值 UAP组最高 ,与 AMI组比较 P <0 .0 1。b.CRP、IL-6、TNF-α三种指标 AMI、UAP组明显增高。UAP组升高尤为突出 ,与 EH组比较 P <0 .0 5。结论 :冠状动脉疾病与炎症反应明显相关 ,在排除其他原因之后 ,血清中 CRP、IL-6、TNF-α水平升高 ,提示冠心病尤其是 AMI、UAP时炎症反应存在 ,此时应用抗生素、阿斯匹林、他汀类药物治疗有益。

Objective: To investigate correlation between inflammatory reaction and coronary heart disease. Methods: This study included 114 patients with acute myocardial infarction(AML group), 39 patients with unstable angina pectoris (UAP group) and 28 patients with essential hypertension (EH group). IgG, IgA, CRP, IL-6, TNF-α were measured in peripheral blood serum samples. Results: (1) Both IgA and IgG level were in normal range in all groups. But IgG level was significantly higher in UAP group than AMI group (P<0 01)。(2) The level of CRP, IL-6, TNF-α were higher in group AMI and UAP than other groups, especially in group UAP, compared with EH group P<0 05. Conclusion: There was a significant positive correlation between inflammatory reaction and coronary heart disease especially in AMI and UAP. Increase of the level of CRP, IL-6 and TNF-α in all subjects indicates inflammatory reaction. Antibiotics, aspirin and tanting drugs may be available.