摘要
目的 对复方甘草甜素和还原型谷胱甘肽治疗慢性乙型肝炎进行经济学评价 ,为临床提供最佳用药方案。 方法 采用随机分组对照进行临床实验观察 ,分析比较复方甘草甜素与还原型谷胱城肽的治疗成本和治疗效果。 结果 复方甘草素和干扰素α-1b治疗慢性乙型肝炎的总有效率分别为 70 .67%和 66.67% ( P>0 .0 5 ) ;成本 -效果比分别为 46.42和 76.44 ( P<0 .0 5 ) ;经敏感度分析所得的成本 -效果比分别为 3 9.45和64 .97。 结论 复方甘草甜素与还原型谷胱甘肽均能有效治疗慢性乙型肝炎 ,但复方甘草甜素比还原型谷胱甘肽更经济 ,更符合药物经济学原则。
OBJECTIVE To evaluate pharmacoeconmics of glycyrrhizin and reduced glutathione in theatment of chronic hepatitis B.METHODS Using pharmacoeconomic cost-effectiveness analysis Reduced glutathione was compared with compound glycyrrhizin in the treatment of 150 patients with chronic hepatitis B(divided into two groups randomly).RESULTS After treatment the effective rates of compound glycyrrhizin and reduced glutathione were 70.67%and 66.67%P>0.05);the cost-effectiveness ratios were 46.42 and76.44 respectively(P<0.05)Cost-effectiveness ratios obtained by seneitivity analysis were 39.45and 64.97 respectively.CONCLUSION In treatment of chronic hepatitis B,Compound glycyrrhizin is more economical than reduced glutathione
出处
《海峡药学》
2004年第5期148-150,共3页
Strait Pharmaceutical Journal
