摘要
2,6-二甲苯胺加氯乙酰氯制得酰胺后与哌嗪反应得N-(2,6-二甲苯基)-2-(1-哌嗪基)乙酰胺,其与由邻甲氧基苯酚和环氧氯丙烷反应得到的2-(2-甲氧苯氧基甲基)环氧乙烷反应制得抗心绞痛药雷诺嗪,总收率51%(以2,6-二甲苯胺计)。
Ranolazine was synthesized from 2,6-dimethylaniline and 2-chloroacetylchloride by amidation andsubsequent condensation with piperazine to give N-(2,6-dimethylphenyl)-2-(1-piperazinyl)acetamide, which subjected tocondensation with 2-(2-methoxyphenoxy)oxirane prepared by condensation of 2-methoxyphenol and epichlorohydrin withan overall yield of 51%(based on 2,6-dimethylaniline).
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2004年第11期641-642,共2页
Chinese Journal of Pharmaceuticals
关键词
雷诺嗪
抗心绞痛药
合成
ranolazine
antianginal drug
synthesis
