摘要
采用乳化-内部凝胶化技术制得载b-榄香烯的海藻酸钙凝胶微球,然后与壳聚糖反应制得b-榄香烯海藻酸钙-壳聚糖微囊。利用激光共聚焦扫描显微镜和激光粒度仪观测所得微囊的形态、粒径及分布,通过气相色谱法考察体外释放性能。结果表明制品球形度好、膜层均匀,粒径呈正态分布,体外释放曲线符合Higuchi方程。
b-Elemene calcium alginate gel microspheres were prepared by emulsification-internal gelatificationtechnology, and then microspheres reacted with chitosan solution to obtain b-elemene calcium alginate-chitosan microcapsules.The shape, diameter and size distribution of the microcapsules were investigated using confocal laser scanning microscopeand laser diffraction particle size analyzer, respectively. In vitro drug release property was examined using gas chromatography.The results showed that b-elemene microcapsules were spherical with uniform membrane thickness and diameters of normaldistribution. The in vitro release property of b-elemene from microcapsules was fitted to the Higuchi kinetics equation.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2004年第11期657-660,共4页
Chinese Journal of Pharmaceuticals
基金
国家自然科学基金项目(20176056)
