超敏C-反应蛋白和血栓前体蛋白对不同程度心功能障碍的诊断价值

Diagnostic Value of High-Sensitivity C-Reactive Protein and Thrombus Precursor Protein on Cardiac Dysfunction.

目的 评价血浆超敏C -反应蛋白 (high -sensitivityC -reactiveprotein ,HSCRP)和血栓前体蛋白 (thrombusprecursorprotein ,TPP)定量测定对不同程度心功能障碍病人心肌损伤的诊断价值。方法 分别测定入院 12h内的 12 8例不同程度心功能障碍病人及 2 0例健康人的HSCRP、TPP ,并作分析比较。结果 实验组HSCRP、TPP浓度水平均高于对照组 (P <0 .0 5 )。心功能Ⅳ级组病人中HSCRP、TPP水平高于心功能Ⅲ级组 ,而心功能Ⅲ级组又高于心功能Ⅱ级组。直线相关分析表明病人体内HSCRP浓度水平与TPP浓度水平呈正相关。结论 HSCRP、TPP是反映心肌损伤的灵敏性较高的生化指标 ,二者测值增高可作为判断心肌损伤程度的辅助指标。

Objective For the evaluating diagnostic value of plasma High-sensitivity C-reactive protein (HSCRP) and thrombus precursor protein(TPP) in myocardial injury to the grades of cardiac dysfunction.Methods HSCRP and TPP in plasma of 128 patients with different grades cardiac dysfunction and 20 normal persons were mensurated and comparatively analyzed.Results The HSCRP and TPP levels of patients group were higher than those of normal group(P<0.05). The HSCRP and TPP levels of patients with cardiac function grade Ⅳ were higher than those of grade Ⅲ,and their levels in grade Ⅲ were higher than those in grade Ⅱ.HSCRP shows positive correlation with TPP by linear regression analysis.Conclusion HSCRP and TPP are good biochemical indexes for myocardial injury. The increased values of HSCRP and TPP can be regarded as auxiliary indexes for diagnosis of myocardial injury.