^(131)I治疗青少年甲亢的疗效观察

Efficacy of ^(131)I Therapy Hyperthyroidism in Adolescent

采用131I治疗了117例青少年甲亢患者,并进行了一定时间的追踪随访,以探讨131I治疗青少年甲亢的可行性。结果显示,在117例患者中,一次治愈76例(占65.0%),好转28例(23.9%),甲减13例(占11.0%),总有效率为88.9%。14岁以下年龄段的患者使用的活度明显低于14岁以上患者组(15～18岁),但两者的治愈率及甲减发生率均无区别;分次治疗可以提高甲亢的治愈率但对甲减发生率无明显影响。因此,131I可以用于治疗青少年甲亢,但在用药剂量上应视年龄给药。

To investigate the possibility of ^(131)I therapy hyperthyroidism in adolescent, 117 adolescent patients treated with ^(131)I are analyzed retrospectively. In the first treatment of ^(131)I, 76 patients gain with euthyroidism (650%), 28 patients have remission(239%), 13 patients have hypothyroidism (110%), the total efficacy is 88.9%. The administered dose to the patients with younger than 14 years is significantly lower than the patients aged from 15 years to 18 years. There is no significantly difference in cure rate or incidence of hypothyroidism between the two groups. The second treatment may improve the cure rate and not exert any significant impact to the incidence of hypothyroidism. Therefore, ^(131)I treatment hyperthyroidism in younger is efficacious, inexpensive and safe. The dosages given to patients are different between age groups.