期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Restin与转录因子的相互作用 被引量：3

原文传递
导出
摘要 Restin 是从维甲酸诱导分化的白血病细胞中克隆的一种黑色素瘤相关抗原家族基因,对细胞增殖具有抑制作用.由于该基因定位于细胞核,且其同源基因Necdin(神经细胞生长抑制因子)与转录因子p53和E2F1具有强烈的相互作用,推测Restin也可能作用于某种转录因子.为此,克隆了转录因子p53,AP1,ATF和E2F,研究Restin与这些转录因子的相互作用.结果发现Restin与ATF3表现出强烈的相互作用.ATF3是细胞应激反应中非常重要的转录因子,推测Restin对细胞增殖的抑制作用可能与ATF3活性的抑制有关.
作者 吴有盛 路凡 齐颖新 王瑞华 张剑 卢兹凡 赵忠良
机构地区 第四军医大学生物化学与分子生物学教研室
出处 《中国科学（C辑）》 CSCD 北大核心 2004年第5期459-464,共6页 Science in China(Series C)
基金 国家自然科学基金资助项目(批准号:30070369)
关键词 转录因子 细胞增殖 抑制作用 相关抗原 E2F1 神经细胞生长 维甲酸 克隆 相互作用 同源基因
分类号 R346 [医药卫生—基础医学]
  • 相关文献

参考文献12

  • 1Chomez P, De Backer O, Bertrand M, et al. An overview of the MAGE gene family with the identification of all human members of the family. Cancer Res, 2001, 61: 5544-5551
  • 2Zhu F, Yan W, Zhao Z L, et al. Related improved PCR-based subtractive hybridization strategy for cloning differentially expressed genes. Biotechniques, 2000, 29(2): 310-313
  • 3Maruyama K, Usami M, Aizawa T, Yoshikawa K. A novel brain-specific mRNA encoding nuclear protein (necdin) expressed in neurally differentiated embryonal carcinoma cells. Biochem Biophys Res Commun, 1991, 178(1): 291～296
  • 4Lucas S, Brasseur F, Boon T. A new MAGE gene with ubiquitous expression does not code for known MAGE antigens recognized by T cells. Cancer Res, 1999, 59, 4100-4103
  • 5Taniura H, Taniguchi N, Hara M, Yoshikawa K. Necdin, a postmiotic neron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1. J Biol Chem, 1998, 273: 720～728
  • 6Taniura H, Matsumoto K, Yoshikawa K. Physical and functional interactions of neuronal growth suppressor necdin with p53. J Biol Chem,1999, 274: 16242-16248
  • 7Salehi A H, Roux P P, Kubu C J, et al. NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis. Neuron, 2000, 27: 279-288
  • 8Liang G S, Wolfgang C D, Hai T, et al. ATF3 gene genomic organization, promoter, and regulation. J Biol Chem, 1996, 271: 1695-1701
  • 9Hai T, Hartman M G. The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis. Gene, 2001, 273: 1～11
  • 10Allan A L, Chris A, Richard G P, et al. Activating transcription factor 3 induces DNAsysthesis and expression of cyclin D1 in hepatocytes. J Biol Chem, 2001, 276, 27272-27280

二级参考文献17

  • 1[1]James S Y, Williams M A, Newland A C, et al. Leukemia cell differentiation: cellular and molecular interactions of retinoids and vitamin D. Gen Pharmacol, 1999, 32(1):143～154
  • 2[2]Howard K. The bioinformatics gold rush. Sci Am, 2000, 283(1): 58～63
  • 3[3]Eisenberg D, Marcotte E M, Xenarios I, et al. Protein function in the post-genomic era. Nature, 2000, 405(6788): 823～826
  • 4[4]Pennisi E. Human genome. Finally, the book of life and instructions for navigating it. Science, 2000, 288(5475): 2304～2307
  • 5[5]Risch N J. Searching for genetic determinants in the new millennium. Nature, 2000, 405(6788): 847～856
  • 6[6]Lin K Y, Wright J, Lim C. Conformational analysis of long spacers in PROSITE patterns. J Mol Biol, 2000, 299(2): 537～548
  • 7[7]Zhao Z, Huang X, Li N, et al. Direct cloning of cell differential expression genes with full-length by a new strategy based on the multiple rounds of "long distance" PCR and magnetic beads mediated subtraction. J Biotech, 1999, 73: 35～41
  • 8[8]Hayashi Y, Matsuyama K, Takagi K, et al. Arrest of cell growth by necdin, a nuclear protein expressed in postmitotic neurons. Biochem Biophys Res Commun, 1995, 213(1): 317～324
  • 9[9]Taniura H, Taniguchi N, Hara M, et al. Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1. J Biol Chem, 1998, 273(2): 720～728
  • 10[10]Taniura H, Matsumoto K, Yoshikawa K. Physical and functional interactions of neuronal growth suppressor necdin with p53. J Biol Chem, 1999, 274(23): 16242～16248

共引文献6

同被引文献30

  • 1李伍举,吴加金.RNA二级结构预测系统构建[J].生物化学与生物物理进展,1996,23(5):449-453. 被引量：12
  • 2van der Bruggen P,Traversari C,Chomez P,Lurquin C,De Plaen E,van den Eynde B,Knuth A,Boon T.A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma.Science,1991,2.54:1643 - 1647.
  • 3Lucas S,De Smet C,Arden K C,Viars C S,Lethe B,Lurquin C,Boon T.Identification of a new MAGE gene with tumor-specific expression by representational difference analysis.Cancer Res,1998,58:743 - 752.
  • 4Lethe B,Lucas S,Michaux L,De Smet C,Godelaine D,Serrano A,De Plaen E,Boon T.LAGE21,a new gene with tumor specificity.Int J Cancer,1998,76:903 - 908.
  • 5Chen M E,Lin S H,Chung L W,Sikes R A.Isolation and characterization of PAGE21 and GAGE27.New genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma associated antigens.J Biol Chem,1998,273:17618 -17625.
  • 6Boel P,Wildmann C,Sensi M L,Brasseur R,Renauld J C,Coulie P,Boon T,van der Bruggen P.BAGE:a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes.Immunity,1995,2:167 - 175.
  • 7van den Eynde B,Peeters O,De Backer O,Gaugler B,Lucas S,Boon T.A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma.J Exp Med,1995,182:689 - 698.
  • 8Zhao Z,Lu F,Zhu F,Yang H,Chai Y B,Chen S M.Cloning and biological comparison of restin,a novel member of Mage superfamily.Sci China C,2002,45(4):412 - 420.
  • 9Zhao Z,Huang X,Li N,Zhu X,Chen S,Cao X.Direct cloning of cell differential expression genes with full-length by a new strategy based on the multiple rounds of "long distance" PCR and magnetic beads mediated subtraction.J Biotech,1999,73:35-41.
  • 10Zhu F,Yan W,Zhao Z L,Chai Y B,Lu F,Wang Q,Peng W D,Yang A G,Wang C J.Improved PCR-based subtractive hybridization,a shortcut to clone novel full length genes.Biotechniques,2000,29(2):310 - 313.

引证文献3

二级引证文献6

中国科学（C辑）
2004年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部