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脑部靶向给药技术 被引量:1

Advances in Brain Targeting Drug Delivery
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摘要 介于脑部毛细血管与脑组织之间的血脑屏障是一层难以通过的生理屏障 ,能够阻挡大多数外源物质进入脑内。临床上采用的中枢神经系统药物大多是能够扩散通过血脑屏障的小分子脂溶性物质 ,而这类药物已经远远不能满足临床需要 ,很多疾病的诊断、治疗需要大分子、水溶性物质。传统的将这类大分子药物导入脑部的方法效果差、危险性大 ,因此近年来针对能够通过血脑屏障脑部靶向给药技术的研究逐渐成为热点。综述了近年来国际上使用嵌合肽。 The blood brain barrier between the brain and the brain capillary endothelial cells is a impermeable barrier, which can prevent most aliens transport into brain. All of the neurotherapeutics that are used in clinical practice at present are small lipid soluble molecules that can diffuse through the BBB. Yet these drugs can no longer meet the clinical needs, many brain neurotherapeutics and neuroprotective drugs are large, water soluble molecules. The usual pathway to deliver large molecules into brain is ineffective and dangerous, therefore the study of brain targeting drug delivery has become a hotspot recent years. This article reviews the advances in brain targeting drug delivery technology such as chimeric peptide technology, PEGylated immunoliposome and nanoparticle technology.
出处 《中国生物工程杂志》 CAS CSCD 2004年第10期1-4,共4页 China Biotechnology
基金 国家自然科学基金资助项目 (3 0 0 70 894)
关键词 脑部 血脑屏障 靶向给药 临床 诊断 治疗 脑内 外源物质 生理 疾病 Blood brain barrier (BBB)Brain targeting drug delivery Chimeric peptide PEGylated immunoliposome Nanoparticle
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参考文献23

  • 1Pardridge WM. Drug and gene targeting to the brain with molecular Trojan horses. Nat Rev Drug Discov, 2002, 1(2) : 131 - 139
  • 2Miller G. Drug targeting. Breaking down barriers. Science, 2002,297: 1116- 1118
  • 3Jefferies WA, Brandon MR, Hunt SV, et al. Transferrin receptor on endothelium of brain capillaries. Nature, 1984, 312 (5990):162 - 163
  • 4Friden PM, Walus LR, Musso GF, et al. Anti-transferrin receptor antibody and antibody-drug conjugates cross the blood-brain barrier. Proc Natl Acad Sci USA, 1991, 88:4771 -4775
  • 5Yoshikawa T, Pardridge WM. Biotin delivery to brain with a covalent conjugate of avidin and a monoclonal antibody to the transferrin receptor. J Pharmacol Exp Ther, 1992, 263:897 - 903
  • 6Pardridge WM, Kang YS, Buciak JL. Transport of human recombinant brain-derived neurotrophic factor (BDNF) through the rat blood-brain barrier in vivo using vector-mediated peptide drug delivery. Pharm Res, 1994, 11:738~746
  • 7Kurihara A, Deguchi Y, Pardridge WM. Epidermal growth factor radiopharmaceuticals: 111In chelation, conjugation to a bloodbrain barrier delivery vector via a biotin-polyethylene linker,pharmacokinetics, and in vivo imaging of experimental brain tumors. Bi
  • 8Pardridge WM, Boado RJ, Kang YS. Vector-mediated delivery of a polyamide (''peptide'') nucleic acid analogue through the bloodbrain barrier in vivo. Proc Natl Acad Sci USA, 1995, 92:5592 -5596
  • 9Kissel K, Hamm S, Schulz M, et al. Immunohistochemical localization of the murine transferrin receptor (TfR) on blood-tissue barriers using a novel anti-TfR monoclonal antibody. Histochem Cell Biol, 1998, 110:63 ~ 72
  • 10Moos T, Morgan EH. Transferrin and transferrin receptor function in brain barrier systems. Cell Mol Neurobiol, 2000, 20: 77 - 95

二级参考文献9

  • 1Rajotte D, Arap W, Hagedorn M, et al. Molecular heterogeneity of the vascular endothelium revealed by in vivo phage display. J Clin Invest, 1998, 102(2): 430-437.
  • 2Rajotte, D. Ruoslahti E. Membrane dipeptidase is the receptor for a lung-targeting peptide identified by in vivo phage display. J Biol Chem, 1999, 274(17): 11593-11598.
  • 3Augustin HG, Kozian DH, Johnson RC. Differentiation of endothelial cells: analysis of the constitutive and activated endothelial cell phenotypes. Bioessays, 1994, 16(2): 901-906.
  • 4Pardridge WM. Non-invasive drug delivery to the human brain using endogenous blood-brain barrier transport systems. Pham Sci Technol Today, 1999, 2(2): 49-59.
  • 5Pasqualini R, Ruoslahti E. Organ targeting in vivo using phage display peptide libraries. Nature, 1996, 380 (6572): 364-366.
  • 6Pardridge WM, Oldendorf WH. Transport of metabolic substrates through the blood-brain barrier. J Neurochem, 1977,28(1): 5-12.
  • 7Muckerheide A, Domen PL, Michael JG. Cationization of protein antigens. Ⅱ. Alteration of regulatory properties. J Immunol, 1987, 138: 2800-2804.
  • 8Pardridge WM, Kang YS, Buciak JL, et al. Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate. Pharm Res, 1995, 12(6): 807-816.
  • 9Pardridge WM, Eisenberg J, Yang J. Human blood-brain barrier insulin receptor. J Neurochem, 1985, 44 ( 6 ): 1771-1778.

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