演化基因体学初介

Introduction to evolutionary genomics

近来 ,人类以及不同模式生物体全基因测序取得的进展 ,为生物学研究提供了一个全新的视角。基于演化起源对直向性同源基因和旁向性同源基因序列的比较 ,可以更好地了解不同基因的生理作用。基因体学研究中的一个重要的方面 ,是了解全部基因的相互关系 ,进而最终可以了解基因的功能。本文提供了几个多肽配体及受体的比较基因体分析的范例。对于这个新生领域 ,本文建议中文名字为“演化基因体学” ,以强调演化过程的非“进步”

Recent advances in the sequencing of all genes in human and diverse model organism have provided a new perspective on biological research. Comparison of the sequences of orthologous and paralogous genes based on their evolutionary origins allows a better understanding of the physiological roles of individual genes. One of the most important aspects of genomic research is the understanding of the entire gene repertoire, thus eventually allowing a full understanding of gene functions. This article provides some examples of comparative genomic analyses of polypeptide ligands and their receptors. The Chinese name for the emerging field of “evolutionary genomics” is proposed here in order to emphasize the non-progressive nature of the evolutionary process and the global analyses of the complete gene sets in diverse organisms.