ANA阴性的系统性红斑狼疮55例临床分析

Clinical analysis of 55 SLE patients with ANA negative

目的探讨ANA阴性的系统性红斑狼疮患者的临床特征。方法对近3年在该院门诊及住院的55例ANA阴性和150例ANA阳性的SLE患者的临床资料进行比较性分析。结果与ANA阳性组相比,ANA阴性组的手足红斑(70.91%,P<0.01)和抗SSA抗体(47.27%,P<0.05)出现的机率较高。肾、血液系统损害(分别为45.45%,16.36%,P<0.05)和抗ds-DNA抗体、抗Sm抗体(分别为34.54%,P<0.01;20.00%,P< 0.05)出现的机率较低。此外,SLE病情活动性评分较低。结论ANA阴性的系统性红斑狼疮皮肤损害多见,较少累及内脏,病情相对稳定。

Objective: To study the clinical features of ANA negative SLE. Methods: The clinical data of 55 ANA negative SLE patients and l50 ANA positive SLE patients in the last three years were comparatively analyzed. Results: Compared with the ANA positive group,the probabilities of occurrence of palms-and-feet erythema (70.91%,P <0.01) and anti-SSA antibody (47.27%, P <0.05) were higher in the ANA negative group, while occurrence of kidney and blood system damage (45.45%,16.36%,P <0.05) and anti-ds-DNA antibody and anti-Sm antibody (34.54%,P <0.01;20.00%,P <0.05)were lower. Additionally, scores of SLEDAI in the ANA negative group were lower. Conclusions: ANA negative SLE mainly does damage to skins,rarely to internal organs. Patients′ conditions are stable comparatively.