SARS患者合并肺炎支原体和肺炎衣原体感染的研究分析

Investigation and analysis of SARS patients with Mycoplasma pneumoniae and Chlamydia pneumoniae complica-ting infection

目的:分析比较SARS患者中肺炎支原体和衣原体感染的水平。方法:收集87例SARS患者、105名血站献血员及116例普通发热患者的血清,分别检测其血清中肺炎支原体和衣原体抗体。统计学分析采用卡方(χ2)检验。结果:SARS病例组的肺炎支原体IgG阳性率(80.5%)高于发热组(56.9%)和正常组(47.6%),IgM在SARS病例组(57.5%)也高于发热组(30.2%),支原体IgG、IgM同时阳性的比较显示,病例组(51.7%)高于正常组(24.8%),并有显著的统计学意义。衣原体的IgG和IgM阳性率在病例组(56.3%和24.3%)均高于正常组(37.1%和11.4%)。结论:在SARS患者中肺炎支原体和衣原体的感染率处于较高水平,需在SARS治疗过程中注意肺炎支原体或肺炎衣原体的合并感染,并对症治疗。

Objective To detect the serum antibodies (IgG/IgM) of Mycoplasma pnuemoniae and Chlamydia pneumoniae in the SARS patients, the general fever patients and the normal people. Methods Eighty-seven SARS patients in Beijing Ditan Hospital from March 2003 to April 2003, 116 inpatients in the respiratory department of Chaoyang Hospital from March 2002 to April 2002, and 105 normal volunteers were studied. The serum antibodies of Mycoplasma pnuemoniae and Chlamydia pneumoniae were detected by the routine methods in our laboratory. χ2 test was used for statistical analysis. Results The positive rates of Mycoplasma pnuemoniae antibody IgG and IgM in SARS patients were both significantly higher than those in the general fever patients and normal volunteers. The positive rates of Chlamydia pneumoniae antibody IgG and IgM in SARS patients were also higher than those in normal people. Conclusions The high infective rate of Mycoplasma pnuemoniae and Chlamydia pneumoniae in SARS patients indicates that we more attention should be paid to the Mycoplasma pnuemoniae and Chlamydia pneumoniae complicating infection or co-infection during the SARS treatment and to treat these infections correctly.