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Tau蛋白在Alzheimers病中的作用研究进展 被引量：15

The role of Tau protein in Alzheimers disease: An update
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摘要 Tau蛋白是一种在神经系统广泛表达的微管相关蛋白 ,起到促进微管形成和稳定微管结构的作用。Tau蛋白过度磷酸化导致Tau蛋白自我聚集成双螺旋纤维细丝 ,进而产生神经纤维缠结 ,该病理改变与阿尔采末病密切相关。围绕tau蛋白的结构、功能 ,在AD病中的病理学意义 ,其与 β 淀粉样肽之间可能存在的相互关系和tau蛋白在诊断和寻找新的AD治疗途径中的应用前景作一综述。 Tau is a microtubule-associated protein th at can promote micortubulbe polymerization in vitro and can stabilize the asse mbled microtubules. Hyperphosphorylated form of tau comprises the main component of the paired helical filaments and neurofibrillary tangles found in Alzheimer s desease (AD). This paper reviews the functions and the prospects of tau in Al zheimers disease.
作者 周宁 杜冠华
机构地区 中国医学科学院药物研究所筛选中心
出处 《中国药理学通报》 CAS CSCD 北大核心 2004年第10期1085-1089,共5页 Chinese Pharmacological Bulletin
基金 国家自然科学基金资助项目 ( 3 0 0 1161940 )
关键词 阿尔采末病 TAU蛋白 微管 神经纤维缠结 tau Alzheimers disease microtubule neurofibrillary tangles.
分类号 R-05 [医药卫生]
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参考文献35

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二级参考文献9

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中国药理学通报
2004年 第10期

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