非可兴奋性内皮细胞α7受体与血管新生

α7 nicotinic receptors in non-excitable endothelium and angiogenesis

烟碱受体α7亚型 (α7nicotinicacetylcholinereceptor,α7nAChR)广泛分布于中枢和外周神经系统 ,是中枢神经系统重要神经递质受体 ,参与神经通路形成、维持和多种生理功能调节。近年来研究发现内皮细胞、血管平滑肌细胞、肺上皮细胞、皮肤角质细胞等非神经元细胞表达α7受体 ,并参与细胞有丝分裂、分化、细胞骨架形成、细胞间联接、运动和迁移等细胞机制调节。体外、体内试验表明α7受体参与内皮细胞多种生物活性物质的分泌和释放 ,参与内皮细胞与其它细胞间信号转导 ,参与内皮细胞血管新生调节。尤其是内皮细胞α7受体与血管新生关系的研究 ,揭示了内皮细胞存在调节血管新生药物作用新靶标。

α7nAChR, an important neurotransmitter recptor,is w il dly expressed in the central and peripheral neuronal system, which is involved i n neuronal signal transduction and the regulation of physiological functions in the central neuronal system. Several studies have demonstrated that α7nAChR is identified in non-neuronal cells such as endothelial cells, vascular smooth mus cle cells, bronchial epithelial cells, skin keralinocytes and is involved in the regulation of mitosis,differentiation, organization of the cytoskeleton, cell -cell contact, locomotion and migration. These (in vitro and in vivo) s tudies indicated that α7nAChR participated in the secretion and release of seve ral bioactivity molecules in endothelial cells, mediated intercellular signal tr ansduction, and regulated angiogenesis. These studies suggested an endogenous ch olinergic target for angiogenesis mediated by endothelial α7nAChR.