急性脑梗死患者血清C反应蛋白水平的变化

The Fluctuation of Serum C-Reaction Protein Level in Patients with Cerebral Infarction

观察急性脑梗死患者血清C反应蛋白的变化规律 ,探讨C反应蛋白在急性脑梗死发病中的作用及临床意义。采用免疫比浊法对 6 6例急性脑梗死患者的血清C反应蛋白水平进行动态观察 (病程第 1、7及 14天 ) ,并与4 5例健康人进行比较。结果发现 ,急性脑梗死患者血清C反应蛋白从病程第 1天即升高 ,明显高于对照组 (P <0 .0 1) ,至第 7天达高峰 ,以后降低 ;重型患者明显高于轻、中型患者。结果提示 ,血清C反应蛋白可能在急性脑梗死的发生、发展中起一定作用 。

Aim To observe the regularity of fluctuation of serum C-reactive protein (CRP) level in patients with acute cerebral infarction (ACI) and to investigate the relationship between the serum CRP level and the development and prognosis of ACI, and its clinical significance. Methods The serum CRP level was determined serially (on day 1, 7 and 14 after onsets) by immune turbidity method in 66 patients with ACI and 45 normal controls. Results In ACI group, the serum CRP level increased on first day was significantly (P<0.01) higher than that in the controls, showing a highest serum CRP level in severe patients. It reached the peak on seventh day and then tended to decrease gradually. Conclusions This study suggests that high serum CRP level may play a role in the development of ACI, and serum CRP level is positivly correlated with severity extent of ACI.