摘要
目的为探讨维生素E对免疫损伤性大鼠肝纤维化的预防作用。方法用猪血清腹腔内注射诱导免疫性肝纤维化模型。以维生素E为预防组 ,秋水仙碱为对照给药组 ,通过灌胃给药 ,每日一次。第 12周处死动物作肝组织病理分析 ,行血清Ⅲ型前胶原 (PC Ⅲ )、透明质酸 (HA)及肝组织脂质过氧化物丙二醛 (MDA)含量测定 ,并行肝组织超氧化物歧化酶 (SOD)活性测定。结果各药物预防组肝纤维程度较模型组轻 ,维生素E能显著地降低血清PC Ⅲ、HA含量及肝组织MDA ,提高肝组织SOD活性 ,呈剂量反应关系。结论维生素E对免疫损伤性肝纤维化有较好的预防作用。
Objective To investigate the prevention action of vitamin E (Vit E) on porcine serum-induced liver fibrosis in rats. Methods The model rats of hepatic fibrosis were induced by intraperitoneal injection of porcine serum. The rats were divided into hepatic fibrosis group、preventive group which was given Vit E every day and colchicines group which was given colchichine every day. The rats were killed at the end of 12nd week. The lover tissue were analyzed by histopathological examination. The serum precollagen type III(PC-III) and hyaluraonic acid (HA),liver maiondiadehyde (MDA) and superoxidedismutase (SOD) were detected. Results The level of hepatic fibrosis in the preventive group was alleviated compared to that of the hepatic fibrosis group. Vit E could decrease the serum PC-III; HA and liver MDA obviously, while it could increase the SOD in liver.Conclusion Vit E shows good effects in the prevention of hepatic fibrosis induced by porcine serum.
出处
《贵州医药》
CAS
2004年第11期963-965,共3页
Guizhou Medical Journal
基金
贵州省科委基金资助 (No 993 0 79)
