摘要
Cataracts are one of the most important causes of blindness. As the mechanism of oxidative damage to cataracts was understood, anti-oxidants, especially peroxidase mimetics, were used to develop the agents to protect the eye and cure cataracts. We have designed and synthesized a nonapeptide (DhHP-6) containing deuterohaemin and histidine, which showed a peroxidase activity by degrading H 2O 2 and tert-butyl hydroxyl radical in ascorbate-specific peroxidase test. The specific activity is 4.0×103 U/μmol with H 2O 2 and ascorbate as the substrate. DhHP-6 is capable of protecting cultured rat lenses from cataracts induced by galactose. In the absence of the DhHP-6 big change on lenses was observed.
Cataracts are one of the most important causes of blindness. As the mechanism of oxidative damage to cataracts was understood, anti-oxidants, especially peroxidase mimetics, were used to develop the agents to protect the eye and cure cataracts. We have designed and synthesized a nonapeptide (DhHP-6) containing deuterohaemin and histidine, which showed a peroxidase activity by degrading H 2O 2 and tert-butyl hydroxyl radical in ascorbate-specific peroxidase test. The specific activity is 4.0×103 U/μmol with H 2O 2 and ascorbate as the substrate. DhHP-6 is capable of protecting cultured rat lenses from cataracts induced by galactose. In the absence of the DhHP-6 big change on lenses was observed.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2004年第11期2171-2173,共3页
Chemical Journal of Chinese Universities
基金
国家自然科学基金 (批准号 :2 970 40 10 )资助
