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脑转移瘤的化学治疗

Chemotherapy for Brain Metastases
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摘要 脑转移瘤是成人最常见的颅内肿瘤。而且它的发生率在不断增高。因为大部分化疗药物被认为不能透过血脑屏障,所以脑转移瘤的化学治疗仍存在很大的争议。实际上,血脑屏障在脑转移瘤中已经被破坏,不能成为限制疗效的因素。最重要的影响脑转移瘤化疗疗效的因素应为原发肿瘤对化疗是否敏感。很多新的化疗药物正在大规模的研究中,其中替莫唑胺(Temodal,temozolomide)被认为是治疗不同的脑转移瘤都比较有效的药物。 Brain metastases are the most common intracranial tumor of adults,and the incidence of brain metastases is increasing.Because the majority of cytotoxic agents seem to be unable to penetrate the blood-brain barrier,the role of chemotherapy in the treatment of brain metastases remains controversial.In the fact,the blood-brain barrier is disrupted in brain metastases,and does not limit the response to chemotherapy. The most important factor affecting the response to cytotoxic agents is the chemosensitivity of different tumors.New- er drugs are now on study:temozolomide seem to be particularly promising(alone or in association with other drugs)in the treatment of various brain metastases.
作者 张雯 储大同
出处 《中国神经肿瘤杂志》 2004年第3期193-196,共4页 Chinese Journal of Neuro-Oncology
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  • 1张夏华,王晓云,章菲菲.替尼泊苷-甲环亚硝脲联合治疗脑转移性肿瘤[J].中国现代应用药学,1999,16(4):66-68. 被引量:4
  • 2G. Robinet,P. Thomas,J. L. Breton,H. Léna,S. Gouva,G. Dabouis,J. Bennouna,P. J. Souquet,P. Balmes,L. Thiberville,P. Fournel,E. Quoix,R. Riou,P. Rebattu,M. Pérol,D. Paillotin,F. Mornex. Results of a phase III study of early versus delayed whole brain radiotherapy with concurrent cisplatin and vinorelbine combination in inoperable brain metastasis of non-small-cell lung cancer: Groupe Fran·ais de Pneumo-Cancérologie (GFPC) Protocol 95-1[J] 2001,Annals of Oncology(1):59~67

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