脑转移瘤的化学治疗

Chemotherapy for Brain Metastases

脑转移瘤是成人最常见的颅内肿瘤。而且它的发生率在不断增高。因为大部分化疗药物被认为不能透过血脑屏障,所以脑转移瘤的化学治疗仍存在很大的争议。实际上,血脑屏障在脑转移瘤中已经被破坏,不能成为限制疗效的因素。最重要的影响脑转移瘤化疗疗效的因素应为原发肿瘤对化疗是否敏感。很多新的化疗药物正在大规模的研究中,其中替莫唑胺(Temodal,temozolomide)被认为是治疗不同的脑转移瘤都比较有效的药物。

Brain metastases are the most common intracranial tumor of adults,and the incidence of brain metastases is increasing.Because the majority of cytotoxic agents seem to be unable to penetrate the blood-brain barrier,the role of chemotherapy in the treatment of brain metastases remains controversial.In the fact,the blood-brain barrier is disrupted in brain metastases,and does not limit the response to chemotherapy. The most important factor affecting the response to cytotoxic agents is the chemosensitivity of different tumors.New- er drugs are now on study:temozolomide seem to be particularly promising(alone or in association with other drugs)in the treatment of various brain metastases.