摘要
背景与目的:自中央性神经细胞瘤和胚胎发育不良性神经上皮瘤(dysembryoplastic neuroepithelialtumors,DNT)被确认以来,脑室外小圆细胞组成的肿瘤受到重视,又报道了乳头状胶质神经元肿瘤(papillaryglioneuronal tumor,PGNT)和节细胞神经细胞瘤等新肿瘤。本文报道一例 PGNT,复习其临床病理特征和文献,对此类肿瘤的特征进行探讨。方法:观察一例新病例的临床和病理表现,包括 HE 和免疫细胞化学染色并复习文献进行讨论。结果:本例(男性,32岁)肿瘤位于大脑顶叶,瘤组织由乳头状结构及少突胶质样细胞和上皮样细胞区交织构成,其中有小圆神经细胞、中等大的神经细胞和大的双核节细胞。免疫细胞化学染色中显示大多数瘤细胞和神经毯呈现 S-100和 Syn 阳性反应,有些瘤细胞呈现 GFAP 阳性反应,本例病理诊断为 PGNT。对肿瘤的临床和病理特征作了讨论,认为 PGNT 为较良性的肿瘤。结论:PGNT 为一种低级别的胶质神经元肿瘤,以特异性乳头状胶质血管结构为特征。免疫细胞化学染色做 NSE,Syn 和 GFAP 等有助与中央性神经细胞瘤、DNT 及其它胶质瘤相鉴别。PGNT 这一新的肿瘤实体有可能成为神经元和混合性神经元胶质肿瘤中的一员。
BACKGROUND & OBJECTIVE:Since the central neurocytoma and the dysembryoplastic neuroepithelial tumors(DNT)were confirmed,more attentions had been paid to the extraventricular small round cell neoplasms.Some cases of the ganglioneutocytoma and the papillary glioneuronal tumor(PGNT)were reported. This paper is to present the clinieopathological features in a new case of PGNT,to review the literatures and to discuss the clinicopathological features of the PGNT.METHODS:Combining with the literatures,the results of the clinical data were reviewed and the tumor tissue sections in HE and immunostain were analyzed.RESULTS: The tumor was located at the parietal lobe of brain in a 32-year old man.The tumor tissues consisted of 3 ar- eas:papillary structure,oligedendroid cells and epitheliod cells.Among them,the small round cells,moderate neu- ronal cells and the large binuclear ganglion cells showed S100 and Syn positive reactions,but some of them showed GFAP positive reaction as astrocytes.The PGNT was diagnosed and its benign clinicopathological evidences were discussed.CONCLUSION:The PGNT was a low-grade glioneuronal tumor with a specific papillary gliovascu- lar structure.The immunostain for the NSE,Syn and GFAP will helpful to differentiate the PGNT from the central neurocytoma,DNT and other gliomas.PGNT,a new tumor entity will become a member of neuronal and mixed neuronal-glial tumors.
出处
《中国神经肿瘤杂志》
2004年第3期218-222,共5页
Chinese Journal of Neuro-Oncology
