鼻咽癌细胞凋亡指数与p73表达及患者临床预后的关系

Relationship between cancer cell apoptosis and p73 expression or prognosis of patients with nasopharyngeal carcinoma

探讨鼻咽癌组织的细胞凋亡情况与p73基因表达、患者临床预后的关系。采用脱氧核糖核酸末端转移酶介导的缺口末端标记技术 (TUNEL)和免疫组化方法检测鼻咽低分化鳞状细胞癌和正常鼻咽黏膜组织。 4 8例鼻咽癌和正常鼻咽黏膜组织的凋亡指数 (AI)无差异。癌组织p73表达与癌细胞AI间无相关关系。癌组织AI与患者性别、年龄、有无复发、临床分期间无明显关系 ,但与患者生存时间呈负相关 (P <0 0 1)。经COX回归分析发现 ,癌组织AI和有无复发均属风险因素。鼻咽低分化鳞状细胞癌不属于高凋亡的肿瘤。p73在鼻咽低分化鳞状细胞癌组织中的表达与癌组织的细胞凋亡无相关关系。

To investigate the relationship between cancer cell apoptosis and p73 expression or prognosis of patients with poorly differenetiated squamous cell carcinama of nasopharynx (NPC). Terminal deoxynucleotidyl transferase-mediated nick end labeling (TUNEL) technique and immunohistochemistry method were applied to detect NPC tissue and normal nasopharyngeal tissue (NNPT). The apoptotic index (AI) of 48 NPC is not different from that of NNPT. The AI had no obvious correlation with the p73 expression in NPC. Althought it was not associated with patients' age, sex , recurrence, clinical profiles, the NPC AI had inversed correlation with the patients' survial time.And the NPC AI and recurrence are independent risk factor by cox regression analysis. The NPC is not an apoptosis-prone tumor. The p73 expression has no correlation with the AI in NPC. The AI of NPC is a prognotic fctor of NPC patients. The patients with higher AI have worse prognosis.