摘要
目的探讨健心平律丸对大鼠心肌缺血再灌注心律失常和水通道蛋白 4 (aquaporin 4 ,AQP4 )的作用。方法应用阻断左冠状动脉造成大鼠心肌缺血再灌注损伤模型。应用心电图Ⅱ导联记录、HE染色和AQP4免疫组化染色方法 ,观察健心平律丸对心肌缺血再灌注心律失常、死亡率、AQP4的影响。结果健心平律丸可明显减少再灌注心律失常发生率及死亡率 ,有减轻心肌缺血水肿损伤 ,增强心肌组织AQP4表达的作用。结论健心平律丸具有抗心肌缺血再灌注心律失常的作用 ,可能与其上调缺血心肌AQP4表达水平 。
Objective To explore the effect of Jianxin Pinglu Pill (JPP) on arrhythmia and aquaporin 4 (AQP4) in rats with myocardial ischemia/reperfusion (I/R) injury. Methods The effects of JPP on arrhythmia, mortality and AQP4 on I/R injured rats model induced by blocking left coronary artery were observed using Ⅱ lead of ECG, HE stain and AQP4 immunohistochemical stain. ResultsJPP showed significant effect in lowering the arrhythmia occurrence and mortality, reducing myocardial ischemic edema and injury, strengthening AQP4 expression in myocardial tissue. Conclusion JPP has the effect of preventing I/R induced arrhythmia, it might be related with its action in up regulating AQP4 expression level in myocardium and reducing the intracellular edema.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2004年第9期823-826,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家自然科学基金资助项目(No .30 371 837)
深圳市医药卫生科技项目 (No.1 9990 4 0 1 7)
