分子印迹技术在固相萃取中的应用与展望

APPLICATIONS AND PROGRESS OF MOLECULAR IMPRINTING TECHNOLOGY IN SOLID PHASE EXTRACTION

0世纪 90年代以来 ,具有构效预定性、特异识别性和广泛实用性等特点的分子印迹技术在异构体及手性分离、化学仿生传感器、模拟酶催化、膜分离及固相萃取等领域的研究较多 .固相萃取技术作为一种比液液萃取更好、更快速、更简便的分离技术 ,是近 30年来才快速发展起来的 .以印迹聚合物作为固相萃取填料是分子印迹技术最具应用前景的一个方向 .对分子印迹技术及固相萃取技术的基本原理及方法进行了简单介绍 ,并着重介绍了近年来分子印迹技术在固相萃取中的应用 ,如环境样品分析、药物分离与分析、生物与临床医学检测等 ,并对两种技术结合取得的成果、面临的问题及应用前景进行了展望 .

Molecular imprinting technology (MIT) with predetermination, specific recognition and practicability is widely used in the domain of biosensor, membrane and isomer separation, antibody mimics, enzyme-mimic catalyst and solid phase extraction (SPE).SPE is a better,more simple and more convenient separation technology than liquid-liquid extraction,and has developed rapidly in recent three decades.It is a hopeful domain that uses molecularly imprinted polymers as solid phase extraction packing (MISPE).In this paper, a brief introduction is given about the origin, principle and methods of molecular imprinting technology and solid phase extraction.MISPE for the purpose of environmental sample analysis, medicine separation, pharmaceutical analysis, clinical inspection, and others is emphasized.The achievement, existent problem and trend of MISPE are also reviewed.76 references are cited.