聚砜微球的双乳液法制备及其吸附特性

POLYSULFONE MICROSPHERES PREPARED BY MIXING TWO EMULSION SYSTEMS AND THEIR ABSORPTION CHARACTERISTICS

根据相转化原理 ,采用双乳液法制备了聚砜微球 ,扫描电镜观察表明制得的聚砜微球粒径较为均一 ,且表面致密 .在微球制备过程中 ,二甲基甲酰胺中的聚砜浓度、两乳液中的连续相 (石蜡 )与分散相 (DMF或水 )的体积比对微球的成球性能有较大影响 .将聚砜微球应用于利尿剂组分的吸附 ,表明其对酸性利尿剂氟咯噻咪和碱性利尿剂氨苯蝶啶有较好吸附 .

According to the principle of phase inversion, polysulfone micorspheres were prepared by mixing two emulsion systems. SEM photos showed that the diameter of microspheres was relatively even and the surface of microspheres was compacted. During the preparation process, the concentration of polysulfone in dimethylformamide (DMF) and the volume ratio of continuous phase (paraffin) versus disperse phase (DMF or water) in the two emulsion systems had significant effect on the characteristics of microspheres. The polysulfone microspheres thus formed showed a good absorption both to the acid stimulant, furosemide and the alkaline stimulant, triamterene.