127例肛门生殖器尖锐湿疣临床病理和免疫组化观察

Anus or Genilatia's Condyloma Acuminatum: a Clinical Pathology and Immumophenotypic Study of 127 Cases

目的 :探讨不同时期尖锐湿疣 (CA)的形态学及免疫组化HPV阳性率。方法 :观察 12 7例不同发生时期CA的临床病理特征 ,免疫组化SP法标记病毒核壳抗原 (HPV -Ag)。结果 :早期 2 5例 ,中期 6 8例 ,晚期 34例。各期光镜下均有不同病理形态学表现。免疫组化HPV检测早期阳性率 2 4 % (6 / 2 5 ) ,中期 5 2 .9% (36 / 6 8) ,晚期 34.3% (12 / 34) ,中期与早晚期相比有明显差异 (P <0 .0 5 )。结论 :CA在不同时期的形态学表现不同 ,且免疫组化阳性率也有差异。

Objective: To study morphologic and immunophenotypic features of condyloma acuminatum(CA) in different stages. Methods: The clinicopathologic features of 127 cases of CA in different stages were studied, the expression of HPV antigen was detected by immunohistochemcal stain. Results: There were 25 cases of early stage, 68 cases of metaphase, 34 cases of expect, and there are different pathology morphological changes in each stage. Immunophenotypic positive rate of early stage, metaphase and expect were 24%, 52.9%, 34.3% respectively. The differences between metaphase and early stage or expect were significant(P<0.05). Conclusion:The morphology of CA was different in different stages and there were significant differences in immunophenotypes.