神经干细胞在恶性脑肿瘤基因治疗中的应用现状及前景

Application and prospect of neural stem cells in gene therapy of malignant brain tumor

神经干细胞 (neuralstemcell,NSC)是具有增殖能力和分化潜能的细胞。神经干细胞的建立和基因修饰技术的完善 ,为基因治疗恶性脑肿瘤提供了可能。目前 ,NSC在恶性脑肿瘤中基因治疗的应用 ,主要包括构建载体和包装病毒载体。

It has been shown that the neural stem cells (NSCs) has the abilitiy of differentiation and proliferation in recent years. The creation of NSC-line and its gene modification makes it possible to act in the gene therapy of malignant brain tumor. At present,the applications of NSC gene therapy of malignant brain tumor mainly includes the construction of carriers and the package of viral vectors. This article summarizes the investigation progress and prospect about it.