非霍奇金淋巴瘤组织p73 mRNA基因表达与病因关系

Relation between p73 mRNA expression and oncogenesis in non-Hodgkin lymphoma

目的 :探讨非霍奇淋巴瘤p73mRNA基因表达与病因的关系。方法 :采用逆转录聚合酶链反应技术 (RT PCR) ,检测 10例非恶性淋巴组织与 40例非霍奇金淋巴瘤组织 p73mR NA基因表达状况。结果 :10例非恶性淋巴组织均有mRNA表达 ( 10 0 % )。 40例非霍奇金淋巴瘤 p73mRNA表达 3 2 5 % ( 13 / 40 ) ,两组表达率差异有统计学意义 ,P <0 0 1。p73mRNA表达与临床分期无关 ,P >0 0 5 ,与病理类型有关 ,P <0 0 5。结论

OBJECTIVE: To explore the relationship between expression of p73 mRNA and oncogenesis in non-Hodgkin lymphoma.METHODS:The expression of p73 mRNA was detected with reverse transcriptase chain reaction (RT-PCR)in 10 case of no tumor lymph node and 40 samples of lymphoma.RESULTS:p73 RNA was expressed in all of no tumor lymph node and 13 of 40 case of lymphoma, which was significantly different between no tumor lymph node and lymphoma. p73 mRNA expression was not related to clinical stages and was significantly related to histological grades.CONSLUSION:p73 gene may contribute to identify lymphomagenesis.