时辰化疗治疗非小细胞肺癌的临床观察

Chrono-chemotherapy for non-small cell lung cancer

为了对比观察CAP方案的时辰化疗与常规化疗的疗效及不良反应 ,对 72例非小细胞肺癌患者 ,用抽签法随机分为时辰化疗组与常规化疗组 ,两组患者的治疗时间不同 ,但用药剂量及化疗周期相同。结果时辰化疗组 3 8例 ,完全缓解率及总有效率分别为 18 4% ( 7/ 3 8)及 5 7 9% ( 2 2 / 3 8) ;常规化疗组 3 4例 ,分别为 2 9% ( 1/ 3 4)及 3 2 3 %( 11/ 3 4)。两组相比差异有统计学意义 ,P =0 0 0 5 6。时辰化疗组Ⅱ度以上的白细胞毒性、消化道毒性的发生率分别为 15 8% ( 6/ 3 8)、2 3 7% ( 9/ 3 8) ,而常规化疗组分别为 5 2 9% ( 18/ 3 4)、67 6% ( 2 3 / 3 4) ,两组相比差异有统计学意义 ,P<0 0 0 1。初步研究结果提示 ,用CAP方案时辰化疗治疗非小细胞肺癌疗效高、毒副反应小 ,明显优于常规化疗 ,且费用低 ,值得临床推广应用。

The objective of this study is to compare the therapeutic effect and side-effect of chrono-chemotherapy with those of routine-chemotherapy. Seventy-two patients with non-small cell lung cancer were divided randomly into chrono-chemotherapy group (38 cases) and routine-chemotherapy group (34 cases).The administration and the dosage were the same for the two groups,but the time of the treatment were different. The CR and the total response rate were 18.4%(7/38) and 57.9%(22/38) in the chrono-chemotherapy group,and 2.9%(1/34) and 32.3%(11/34) in the routine-chemotherapy group.There were significant differences between the two groups,P=0.005 6. Side-effects were as following:the rates of toxicity of bone marrow≥Ⅱ0 and digestive tract reaction were 15.8%(6/38) and 23.7%(9/38)in the chrono-chemotherapy group,and 52.9%(18/34) and 67.6%(23/34) in the routine-chemotherapy group.There were significant differences between the two groups,P<0.001. In conclusion,for non-small cell lung cancer,chrono-chemotherapy with CAP has a high curative effect and low side-effects.