当归微粉的特征及对阿魏酸溶出的影响

Effect of micronization on the powder characteristic of Angelica Sinennsis and extraction of ferulic acid

目的 :比较当归普通粉和微粉的粉体学特征、水溶性及醇溶性浸出物含量、指标成分阿魏酸溶出量 ,探索微粉化技术在当归中的应用价值。方法 :通过激光粒度分析仪对普通粉和微粉进行表征 ,扫描电镜 (SEM )观察普通粉和细粉的表面形态 ,测定粉体学参数休止角和堆密度 ,冷浸法测定水溶性及热浸法测定醇溶性溶出物的含量 ,利用超声提取进行水溶性指标成分阿魏酸的溶出实验 ,采用HPLC测定阿魏酸的含量。结果 :当归普通粉和微粉的粉体学特征及表面形态差异显著 ,但水溶性及醇溶性浸出物量、水溶性指标成分阿魏酸的溶出差别不大。结论 :微粉化应用于当归 ,通过对粉体学特征的影响而影响其制剂学性质 ,但不能显著提高其醇溶性及水溶性浸出物和指标成分阿魏酸的溶出量 ,生产中不宜对当归进行微粉化。目的 :比较当归普通粉和微粉的粉体学特征、水溶性及醇溶性浸出物含量、指标成分阿魏酸溶出量 ,探索微粉化技术在当归中的应用价值。方法 :通过激光粒度分析仪对普通粉和微粉进行表征 ,扫描电镜 (SEM )观察普通粉和细粉的表面形态 ,测定粉体学参数休止角和堆密度 ,冷浸法测定水溶性及热浸法测定醇溶性溶出物的含量 ,利用超声提取进行水溶性指标成分阿魏酸的溶出实验 ,采用HPLC测定阿魏酸的含量。结果 :当归普通粉和微?

AIM: The powder characteristic, water and ethanol extraction amount, extraction amount of active ingredient ferulic acid were comparatively studied between crude powder and micronized powder to explore the application of micronization technology to Angelica Sinennsis. METHODS: Angelica Sinennsis powder was characterized by laser diffraction analyzer and scanning electron microscopy, the angle of repose and bulk density were measured, the water and ethanol extraction were quantified by cooled and heated extraction, the active ingredient ferulic acid was detected by RP HPLC after it released from Angelica Sinennsis. RESULTS: The differences of particle characteristic and surface morphology between the crude and superfine powder were significant, however, water and enthanol extraction amount were not increased markedlky, the dissolution amount of ferulic acid was almost the same. CONCLUSION: Pharmaceutical characteristic of Angelica Sinennsis powder is affected by micronization, but its bioavailability is not improved. Micronization technology is not suitable to Angelica Sinennsis.