氯诺昔康及曲马多用于肠道手术后自控镇痛的比较研究

Comparison of Patient-controlled Analgesia With Lornoxicam Vers us Tramadol in Patients Undergoing Intestinectomy

目的 :评价氯诺昔康及曲马多用于肠道手术后患者自控镇痛 (PCA)的安全性及有效性。方法 :5 0例在全麻下行肠道肿瘤切除术的患者 ,随机分为氯诺昔康组 (L组 )和曲马多组 (T组 ) ,每组各 2 5例。将所配制药液注入PCA泵 ,设定PCA泵给药速率为 2ml/h ,术毕时启动PCA泵进行镇痛 ,镇痛完毕后由患者完成对疼痛的评分 ,并记录发生的副作用。结果 :在病人镇痛总体印象评分中 ,L组镇痛满意的比例略高于T组 ,但无统计学差异。T组恶心与呕吐的发生率明显高于L组。结论 :氯诺昔康用于肠道肿瘤切除术后PCA的效果与曲马多接近 ,但副作用少 ,更适用于急性疼痛的治疗。

Objective:To assess the analgesic efficacy and safety of p ati ent-controlled analgesia with lornxicam or tramadol in patients undergoing intes tinectomy.Methods:50 patients scheduled for intestinectomy under general anesthe sia were randomly allocated to lornoxicam(Group L) and tramadol (Group T) for po stoperative patient-controlled analgesia(PCA). Efficacy was assessed by a 5-poin t verbal rating scores of pain intensity. Possible adverse events were also reco rded.Results:Statistical analysis revealed no significant difference in a 5-poin t verbal rating scores of pain intensity between lornoxicam and tramadol.Lornoxi cam caused fewer side effects such as nausea and vomiting than tramadol.Conclusi on:Lornoxicam offers a useful alternative to tramadol with less side effects fo r the patient-controlled analgesia of postoperative pain.