282株肠球菌的分布及耐药性分析

The characters of distribution and resistance of Enterococcus

目的了解临床感染肠球菌的分布及耐药特点。方法用VITEK60微生物鉴定和药敏分析系统对从临床标本中分离的282株肠球菌进行鉴定和药敏试验,用头孢硝噻吩检测菌株的β内酰胺酶。结果282株肠球菌中,屎肠球菌占422%,粪肠球菌占390%,其他肠球菌占188%;分离率较高的标本依次为尿液、痰液、粪便和胆汁,分别占387%、170%、156%和128%;肠球菌对抗菌药物的耐药性存在明显的种间差异,屎肠球菌和酪黄肠球菌的耐药率明显高于粪肠球菌和鸟肠球菌;共检出β内酰胺酶阳性株2株,占07%,万古霉素中介和耐药菌株各占35%和39%,且905%的菌株分离自胆汁和大便标本。结论肠球菌可引起临床各类感染,多重耐药肠球菌分离率及万古霉素敏感性降低菌株不断出现,应引起临床重视。

Objective To investigate the distribution and resistance of Enterococcus infection, and provide the guideline for control and treatment Enterococcus infection.Methods Enterococcus resistance was tested using VITEK AMS,β lactamase was detected by Nitrocefin methods. Results Among 282 Enterococeus, E.faecium,E.faecalis and other Enterococcus were 42 2%, 39 0% and 18 8% respectively; The most common source of specimen were urine(38 7%),sputum(17 0%),feces(15 6),bile(12 8%). E.faecium and E.casselifiavus resistance tomost antibiotics were higher than E.faecalis and E.avium;β lactamase positive strains accounted for 2(0 7%);VIE and VRE were 3 5% and 3 9% respectively; among this strains 90 5%were from feces and bile.Conclusions Enterococcus can cause various infection, VIE ,VILE and high drug resistance Enterococcus were increasing frequently, It should be detected and treated carefully.