雷莫司琼防治肺癌化疗所致胃肠道反应2种用法的疗效观察被引量：2

Efficacy Observation of Two Methods of Ramosetron for Prevention of Gastrointestinal Reaction Associated with Lung Cancer Chemotherapy

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摘要目的　观察雷莫司琼预防顺铂引起胃肠道反应的疗效 ,并探讨其更有效的临床使用方法。方法　采用随机对照 ,入选患者随机分为雷莫司琼 0 .3mg 1d用药组 (A组 )和 3d用药组 (B组 )。结果　可评价患者 4 7例 ,1d药组 2 3例 ,3d用药组 2 4例。化疗后雷莫司琼对恶心的控制率为 85 .1% ,A、B 2组间无统计学差异 (P >0 .0 5 )。对止吐的有效率为 89.4 % ,A、B 2组间也无统计学差异 (P >0 .0 5 )。不良反应主要为头痛。结论　雷莫司琼是安全、高效的止吐药物 ,具有药效经济学优势。 Objective To observe the efficacy of ramosetron I the prophylaxis of gastrointestinal reaction induced by cisplatin and find a better method in clinical application. Methods Chemotherapy patients with histologically confirmed non-small cell lung cancer were randomized to receive ramosetron 0.3 mg one day ( group A) and three days (group B). Results A total of 47 patients entered the study being evaluable for response, of whom 23 received ramosetron one day and 24 received three days. The rates of ramosetron controlling nausea and vomiting were 85.1% and 89.4%, respectively and no statistically significant difference between group A and group B. The most common adverse event was headache. Conclusion Ramosetron might be a safe and effective antiemetic and have the superiority in cost-effectiveness.

作者郝杰李晔

机构地区哈尔滨市血液肿瘤研究所哈尔滨医科大学第一临床医学院

出处《黑龙江医学》 2004年第11期814-815,共2页 Heilongjiang Medical Journal

关键词肿瘤学雷莫司琼顺铂胃肠道反应 Ramosetron Cisplantin Gastrointestinal reaction

分类号 R734.2 [医药卫生—肿瘤]

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