抗焦虑抑郁药物对伴焦虑抑郁的高血压患者的治疗效果及其临床意义

The Effects and Clinical Implications of Drug Therapy on Anxiety and Depression of patients will Essential Hypertension

目的 :探讨抗焦虑抑郁药物治疗对伴发焦虑抑郁的高血压患者的治疗效果及其临床意义。方法 :对 77例高血压患者进行SDS、SAS评分 ,将评分阳性者随机分为实验组 (常规治疗 +抗焦虑抑郁剂 :赛乐特 )及对照组 (仅用常规治疗 ) ,并随访 12周 ;评分阴性者为无焦虑抑郁组。比较三组自觉症状缓解时间、住院日、药费和临床疗效 ,以及两组 (实验组与对照组 )的SDS、SAS、QOL得分。结果 :实验组、无焦虑抑郁组较对照组的自觉症状缓解时间明显缩短、药费明显降低 ,住院日缩短 ,临床疗效明显提高 ,实验组SDS、SAS评分显著低于对照组 ,且 3项QOL评分显著高于对照组。结论 :抗焦虑抑郁药物治疗能缩短自觉症状缓解时间及住院日 ,降低医疗费用 ,并能明显提高临床疗效 ,显著降低高血压患者焦虑、抑郁的严重程度 。

Objective:To investigate the effects of Seroxat on Essential Hypertensive subjects with anxiety and depression and to explore its clinical implications. Methods:After evaluating 77 cases with essential hypertension by SDS and SAS, the subjects with positive results who were followed for 12 weeks from baseline assessments were randomly divided into experimental group (routine treatment and Seroxat) and control group(only routine treatment) and the subjects with negative results were regarded as non-anxiety and non-depression group. The time of the amelioration of symptom , the duration of hospitalization, the drug costs and clinical outcome were compared between 3 groups. The scores of SDS\SAS\QOL were compared within and between the experimental and control group.Results: In experimental groups and non-anxiety and non-depression groups, the time of the amelioration of symptom and the duration of hospitalization were shorter, the drug costs were less and clinical outcome was significantly better than those of control group. The scores of SDS and SAS in experimental groups were significantly lower and the scores of 3 items of QOL were significantly higher than those of control groups.Conclusion:The drug therapy on anxiety and depression could shorter the time of the amelioration of symptom, the duration of hospitalization, decrease the drug costs in hospital, significantly improve clinical outcome, and also lower the degree of psychological obstacle, improve quality of life of essential hypertension patients.