摘要
目的 探讨癌基因c fos、c jun的表达与皮肤鳞癌发生和发展的关系。 方法 采用免疫组化法对 6 0例皮肤鳞癌的c fos、c jun的表达情况进行检测 ,并与正常皮肤组织进行对照。 结果 c fos、c jun在正常皮肤组织不表达 ,在皮肤鳞癌中的表达阳性率分别为 6 1.7%和 4 8.3% ,其表达水平与癌组织的分化程度有关 (P <0 .0 5 ) ,肿瘤的分化程度越高其表达水平越高。 结论 c fos、c jun的表达水平可作为判定皮肤鳞癌分化的指标。
Objective To explore the expressions of c-fo s, c-jun in skin cell squamous carcinoma and their relations to the occurrence an d development of the tumor. Methods The expressions of c -fos、c-jun in 60 cases of skin squamous cell carcinoma were detected by im munohistochemical method, and compared them with nomal tissues. Results There were no expressions of c-fos and c-jun in nomal skin. Howe ver, in skin squamous cell carcinoma, the positive rates of c-fos and c-jun were 61.7% and 48.3%,respectively. The expression levels of c-fos and c-ju n were related to the degree of differentiation (P<0.05). Upreg ulated expressions of c-fos and c-jun were strongly associated with hig her differentiation. Conclusion The expression levels of c- fos and c-jun may be an index to determine the degree of differentiation.
出处
《现代实用医学》
2004年第9期527-529,共3页
Modern Practical Medicine
