云南省三个民族人群幽门螺杆菌甲硝唑耐药调查

Study on metronidazole resistance to Helicobacter pylori from three populations with different ethnics in Yunnan

目的 调查和分析云南省不同民族幽门螺杆菌(H.pylori)菌株对甲硝唑耐药的流行情况。方法 用E-test方法检测109株H.pylori菌株(汉族人群分离33株、白族31株、纳西族45株)对甲硝唑的敏感性。结果 云南地区甲硝唑耐药率为67.89％。汉族、白族、纳西族H.pylori对甲硝唑耐药率在统计学上差异无显著性。云南地区和三个民族H.pylori菌株的甲硝唑耐药率在年龄、上消化道疾病的分布上差异无显著性;但在性别方面,汉族男性组甲硝唑耐药率为50.00％,低于女性组的90.91％(X^2=5.304,P=0.027);而白族和纳西族中性别在H.pylori对甲硝唑耐药率上差异无显著性。结论 云南地区H.pylori对甲硝唑耐药率高,汉族、白族、纳西族在选择治疗H.pylori感染的抗生素时,可以忽略民族间的差异。

Objective To evaluate the prevalence of Helicobacter pylori (H. pylori ) resistance to metronidazole among three populations in Yunnan. Methods Susceptibilities to metronidazole among 109 H. pylori strains(33 H. pylori strains from Han, 31 H. pylori strains from Bai and 45 H. pylori strains from Naxi ethnic populations)were tested by Epsilometer test(E-test). Results In 109 H. pylori strains, the overall metronidazole resistantce rate was 67.89%. There were no significant difference in the metronidazole resistant rates of H. pylori among Han, Bai, Naxi populations Yunnan in terms of the distribution on age and upper gastroduodenal diseases. In the facet of gender, metronidazole resistant rate of H. pylori was significantly lower in Han males than in females(X^2=5. 304, P=0. 027), but not seen in the Bai or Naxi peoples. Conclusion Metronidazole resistance rate of H. pylori in Yunnan was high, but no significant difference was found among Han, Bai, Naxi peoples in the province.