二水一碘羧酸根合铂(II)混配配合物的合成及其抗肿瘤活性

Synthesis and antitumor activities of diaqua platinum(II) complexes with carboxylates and iodo.

首次合成四种二水一碘羧酸根合铂类配合物[Pt(II)(H2O)2I(OCOR)](I～IV)(R=—C6H4NO2,—C6H4NH2,—CH2Cl,—CHCl2).用元素分析、摩尔电导、差热热重分析、红外光谱、紫外光谱和核磁共振氢谱对其进行了表征.体外抗肿瘤活性表明,四种配合物对所试的肿瘤细胞表现出较低的活性,只有在10μM浓度下配合物才仅对某些肿瘤细胞有一定的增殖抑制作用.

The complexes of the type\ (I^IV)(R=—C_6H_4NO_2,—C_6H_4NH_2,—CH_2Cl,—CHCl_2) were synthesized for the first time. They were characterized by elemental analysis, molar conductance, differential thermal analysis and spectral(IR, UV, ()~1HNMR) studies. The results indicated that complexes I^IV had poor activities against human tumor cell lines in vitro and only have limited antiproliferative effects against some human tumor cell lines at concentration of 10 μM.