男性饮酒与缺血性脑卒中发病关系的研究

Alcohol consumption and incidence of ischemic stroke in male Chinese

目的 探讨中国男性人群中饮酒与缺血性脑卒中发病的关系。方法 1982～1985年在全国10组人群中分别整群随机抽取2000～4000人进行饮酒及心血管病危险因素调查,并对其中无冠心病、脑卒中及恶性肿瘤者脑卒中事件的发生情况进行随访观察,随访至1999～2000年,平均随访15.2年。结果 在12352名男性中共发生缺血性脑卒中283例。在控制了多种危险因素后,每日饮酒量(酒精含量)在0～、15～、30～和60g各组与不饮酒者相比,发生缺血性脑卒中的相对危险(OR值95％CI)分别为0.86(0.57～1.27)、1.20(0.87～1.65)、1.26(0.86～1.84)、1.96(1.30～2.93)。结论 在中国男性人群中,小量饮酒并不增加缺血性脑卒中发生的危险性,大量饮酒会使缺血性脑卒中发生的危险明显增加。

Objective To assess the relationship between incidence of ischemic stroke and alcohol consumption. Methods The information on alcohol consumption and other cardiovascular risk factors such as SBP, DBP, TC was collected among 10 populations in northern and southern parts of China according to the international standardized methods. A total number of 30 560 men and women aged 35-59 were enrolled and followed up for an average of 15.2 years. Complete data on 12 352 men was analyzed. Results The risk on ischemic stroke incidence showed a graded association. Compared with nondrinkers, the relative risks of incidence of ischemic stroke for those who drank alchol less then 15 gram per day, 15-30 gram per day, 30-60 gram per day, above 60 gram per day were 0.86(95% confidence interval 0.57-1.27), 1.20(0.87-1.65), 1.26(0.86-1.84) and 1.96(1.30-2.93), respectively. Conclusion Our study revealed that in male Chinese, heavy alchol intake significantly increased the risk while mild alcohol drinking did not increase the risk of ischemic stroke.