国产八氟丙烷微泡造影剂左心室超声显像效果研究

Efficacy of a new microbubble contrast agent of C_3F_8 in opacification of left ventricle

目的 评价八氟丙烷微泡超声造影剂 (C3 F8)的左心室超声显像效果。方法 7头实验猪分别接受低剂量 ( 0 .0 0 2ml/kg)和高剂量 ( 0 .0 2ml/kg)C3 F8静脉注射 ,观察造影剂注射前后左心室显影等级、左室内膜边界改善效果和Simpson法左室射血分数测定 ,同时评价其对实验猪的心率、呼吸的影响。 结果 C3 F8注射后左室显影等级强度和内膜边界增强节段数均显著改善 ,部分心肌也可以显影 ;对心率和呼吸未见明显影响。结论 经静脉注射C3 F8可使得左心室显影明显增强 ,显著改善左心室内膜边界显示 ,安全性好。

Objective To evaluate the efficacy of a new micro-bubble contrast agent of C_3F_8 in the opacification of the left ventricle. Methods Seven pigs received a bolus injection of C_3F_8 (0.002) and (0.02) (ml/kg) intravenously. Left ventricular opacification grades and number of endocardial border delineation segments were observed and left ventricular ejection fraction(LVEF) were measured using modified Simpson method after each intravenous contrast injection. Heart rate and respiration rate were recorded before and after each injection. Results There was a significant improvement for every measurement of contrast enhancement in each intravenous injection. In addition, part of myocardial tissue could be enhanced after contrast injection. There was no difference in heart rate and respiration rate between pre- and post-injection. Conclusions This new contrast agent is safe and helpful in delineating endocardial border of the left ventricle.