肾上腺髓质素拮抗胰岛素抵抗

Adrenomedullin against insulin resistance

为研究氧化应激与高血压和胰岛素抵抗的关系 ,应用 8周龄雄性的肾上腺髓质素基因敲除小鼠与野生型小鼠对照 ,经血管紧张素Ⅱ刺激 2 8天 ,并给予一种超氧化物岐化酶拟似物— 4 羟基 2 ,2 ,6,6 四甲基六氢吡啶 N 氧 (羟基 TEMPOL) ,结果发现 。

To reveal the involvement of oxidative stress in hypertension and insulin resistance. Angiotensin Ⅱ was given to adrenomedullin-knockout mice for 4 weeks. 4-Hydroxy-TEMPOL, a superoxide scavenger mimetic was also employed. The results suggested that adrenomedullin may exert a protective effect against insulin resistance via its intrinsic antioxidant effect.