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细胞凋亡通路激活对实验性1型糖尿病树胰岛β细胞死亡的作用 被引量:1

Effect of apoptosis pathway activation on the damage of β cells in tree shrew with experimental type 1 diabetes mellitus
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摘要 树 2 6只分为正常对照组和 1型糖尿病组。小量、多次链脲佐菌素注射可诱导树产生 1型糖尿病 ,其 β细胞损伤与胰岛中细胞凋亡通路激活有关。 Twenty-six tree shrews were assigned to the control group and type 1 diabetes mellitus-induced group. The pathogenesis of type 1 diabetes mellitus in tree shrews induced by multiple intravenous injection with low dose of streptozotocin may be related to the activation of apoptosis pathway.
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2004年第5期472-473,共2页 Chinese Journal of Endocrinology and Metabolism
基金 广西区科委基金资助 (0 1 350 2 4 )
关键词 1型糖尿病 树鼩 细胞凋亡 胰岛Β细胞 激活 实验性 死亡 通路 链脲佐菌素 Apoptosis Tree shrew Diabetes mellitus, type 1 Animal model
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  • 1P. Augstein,A. G. Elefanty,J. Allison,L. C. Harrison. Apoptosis and beta-cell destruction in pancreatic islets of NOD mice with spontaneous and cyclophosphamide-accelerated diabetes[J] 1998,Diabetologia(11):1381~1388

同被引文献4

  • 1Marc Yves Donath.2型糖尿病患者β细胞减少的机制与临床启示[J].国际内分泌代谢杂志,2006,26(3):191-192. 被引量:2
  • 2Butler AE,Janson J,Walter C,et al.Increased B-cell apoptosis prevents adaptive increase in B-cell mass in mouse model of type 2 diabetes:evidence for role of islet amyloid formation rather than direct action of amyloid[J].Diabetes,2003,52:2 304-2 314.
  • 3Lambert AE,Blondel B,Kanazawa Y,et al.Monolayer cell culture of neonatal rat pancreas:light microscopy and evidence for immunoreactive insulin synthesis and release[J].Endocrinology,1972,90(1):239-248.
  • 4Butler AE,Janson J,Bonner-Weir S,et al.Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes[J].Diabetes,2003,52:102-110.

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